Regional Health Clinical Research

Current clinical trials

Brain
CTSU E3F05 Phase III Study of Radiation Therapy with or without Temozlomide for Sympotomatic or Progressive Low-Grade Gliomas

NCCTG N057K Phase I/II Evaluation of Everolimus (RAD-001), Radiation and Temozolomide (TMZ) Followed by Adjuvant Temozolomide and Everolimus in Newly Diagnosed Glioblastoma

NCCTG N0877 Phase I/Randomized Phase II Trial of Either Dasatinib or Placebo Combined with Standard Chemo-Radiotherapy for Newly Diagnosed Glioblastoma Multiforme

NCCTG N0572 A Phase I/II Trial of Sorafenib and CCI-779 in Recurrent Glioblastoma

NCCTG N0872 Phase I/II Study of Dasatinib/Bevacizumab in Recurrent Glioblastoma

CTSU R0834 Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma

CTSU N0577 Phase III Intergroup Study of Radiotherapy vs Temozolomide Alone vs Radiotherapy with Concomitant and Adjuvant Temozolomide for Patient with 1p/19q Codeleted Anaplastic Glioma

RTOG 0837 Phase II Randomized Study of Conventional Chemoradiotherapy and Adjuvant Temozolomide With Versus Without Cediranib Maleate in Patients With Newly Diagnosed Glioblastoma

NCCTG N0874 Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

RTOG 0933 Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

Breast
N0937 Phase II Trial of Brostallicin and Cisplatin in Patients with Metastatic Triple Negative Breast Cancer

MA32 A Phase III Randomized Trial of Metformin vs Placebo on Recurrence and Survival in Early Breast Cancer

CTSU NSABP B-39 Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer

RTOG 1005 Phase III Randomized Study of Accelerated Hypofractionated Whole-Breast Irradiation and Concurrent Boost Versus Standard Whole-Breast Irradiation and Sequential Boost in Patients With Early-Stage Breast Cancer After Lumpectomy

CTSU B-47 Phase III Randomized Study of Adjuvant Chemotherapy With Versus Without Trastuzumab in Women With Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer

CTSU S1007 Phase III Randomized Study of Standard Adjuvant Endocrine Therapy With Versus Without Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive, and HER2-Negative Breast Cancer

RTOG 1014 Phase II Study of 3D-Conformal Partial-Breast Re-irradiation in Women With Locally Recurrent Breast Carcinoma Previously Treated With Repeat Breast-Preserving Surgery

CTSU S0800 Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Doxorubicin, Cyclophosphamide, and Pegfilgrastim With or Without Bevacizumab in Treating Women With Inflammatory or Locally Advanced Breast Cancer

Symptom Management
N08CB Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium in Two Different Versions to Prevent Oxaliplatin-Induced Sensory Neuropathy

RTOG 0631 Phase II/III Study of Image-Guided Radiosurgey/SBRT for Localized Spine Metastasis

NCCTG 94-72-53 Diagnostic and Prognostic Markers in Low-Grade Glioma (Block/Ancillary Study)

NCCTG 94-72-53 Diagnostic and Prognostic Markers in Low-Grade Glioma

NCCTG N0477 Optimizing EGFR Inhibitor-Based Therapies for GBM

NCCTG N08C1 Paclitaxel-Associated Acute Pain Syndrome Natural History Study

RTOG 0831 A Randomized, Double-Blinded, Placebo-Controlled Phase III Trial to Evaluate the Effectiveness of a Phosphodiesterase 5 Inhibitor, Tadalafil, in Prevention of erectile Dysfunction in Patients Treated with Radiotherapy for Prostate Cancer

NCCTG N10C2 Magnesium Oxide in Treating Postmenopausal Women With Hot Flashes and a History of Breast Cancer

CTSU SCUSF 0806 Lisinopril or Carvedilol Phosphate in Reducing Side Effects in Women With HER2-Positive Breast Cancer Receiving Trastuzumab

Colon
C80702 A Phase III Trial of 6 vs 12 Treatments of Adjuvant FOLFOX plus Celecoxib or Placebo for Patients with Resected Stage III Colon Cancer

CTSU C80405 A Phase III Trial of Irinotecan/5 FU/Leucovorin or Oxaliplatin/5 FU/Leucovorin with Bevacizumab, or Cetuximab, or with the Combination of Bevacizumab and Cetuximab for Patients with Untreated Metastatic Adenocarcinoma of the Colon or Rectum

CTSU N0949 Phase III Randomized Study of mFOLFOX7 or XELOX Plus Bevacizumab Versus Fluorouracil/Leucovorin Calcium or Capecitabine Plus Bevacizumab as First-Line Therapy in Elderly Patients With Metastatic Colorectal Cancer

CTSU NSABP P-5 Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery

Rectal
No current studies

Esophagus
RTOG 0436 A Phase III Trial Evaluating the Addition of Cetuximab to Pacliataxel, Cisplatin, and Radiation for Patients with Esophageal Cancer who are Treated without Surgery

Pancreas
RTOG 0848 Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed By Chemotherapy With or Without Radiation Therapy in Treating Patients With Pancreatic Cancer That Has Been Removed By Surgery

Hepatocellular
CTSU C80802 Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancer

Small Bowel
NCCTG N0543 A Phase II Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy for Advanced Small Bowel Adenocarcinoma

Prostate
RTOG 0815 Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy with or without Short-Term Androgen Deprivation Therapy for Patients with Intermediate-Risk Prostate Cancer

RTOG 0534 Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA after Radical Prostatectomy

RTOG 0938 Radiation Therapy in Treating Patients With Prostate Cancer

Renal Cell (kidney)
CTSU S0931 Phase III Randomized Study of Everolimus Versus Placebo in Patients With Renal Cell Carcinoma Who Have Undergone Nephrectomy or Partial Nephrectomy

CTSU S0931 Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery

Head and Neck
0920 Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetxuimab for Locally-Advanced Resected Head and Neck Cancer

CTSU E1305 Phase III Randomized Trial of Chemotherapy with or without Bevacizumab in Patients with Recurrent or Metastatic Head and Neck Cancer

RTOG 1008 Phase II Randomized Study of Adjuvant Radiotherapy With Versus Without Concurrent Chemotherapy in Patients With Resected High-Risk Malignant Salivary Gland Tumors

RTOG 1016 Phase III Randomized Study of Radiotherapy With Cisplatin or Cetuximab in Patients With Human Papilloma Virus-Associated Oropharyngeal Cancer

Lymphoma
NCCTG N078D Phase I/II Trial of Rituximab, Cladribine, and Temsirolimus (RCT) Therapy in Newly Diagnosed Mantle Cell Lymphoma (MCL)

Myelodysplastic Syndrome
(none at this time)

Multiple Myeloma
CTSU E3A06 Phase II Pilot Study Followed by a Phase III Randomized Study of Lenalidomide Versus Observation Alone in Patients with Asymptomatic High-Risk Smoldering Multiple Myeloma

Lung
N0923 A Randomized Double-Blinded Phase II Study of NTX-010, a Replication-Competent Picornavirus, After Standard Platinum-Containing Cytoreductive Induction Chemotherapy in Patients with Extensive Stage Small Cell Lung Cancer

0937 Randomized Phase II Study Comparing Prophylactic Cranial Irradiation alone to Prophylactic Cranial irradiation for Extensive Disease Small Cell Lung Cancer

CTSU E1505 A Phase III Randomized Trial of Adjuvant Chemotherapy with or without Bevacizumab for Patients with Completely Resected Stage IB (greater than or equal to 4 cm) - IIIA Non-Small Cell Lung Cancer

CTSU S0819 Randomized Phase III Study Comparing Carboplatin/Paclitaxel or Carboplatin/Paclitaxel/Bevacizumabwith or without Concurrent Cetuximab in Patients with Advanced NSCLC

CTSU C30607 Phase III Double-blind Placebo-controlled Trial of Sunitinib as Maintenance Therapy in Non-Progressing Patients Following an Initial Four Cycles of Platinum-based Combination Chemotherapy in Advanced, Stage IIIB/IV NSCLC

CTSU C30801 A Randomized Phase III Double Blind Trial Evaluating Selective COX-2 Inhibition in COX-2 Epressing Advanced NSCLC

CTSU Z4099 Phase III Randomized Study of Sublobar Resection With or Without Brachytherapy Versus Stereotactic Body Radiotherapy in High-Risk Patients With Stage I Non-Small Cell Lung Cancer

CTSU E5508 Phase III Randomized Study of Maintenance Therapy Comprising Bevacizumab Versus Pemetrexed Disodium Versus Bevacizumab and Pemetrexed Disodium Following Induction Therapy With Carboplatin, Paclitaxel, and Bevacizumab in Patients With Advanced Non-Squamous Non-Small Cell Lung Cancer

Melanoma
N0879 A Randomized Phase II Trial of Carboplatin, Paclitaxel, Bevacizumab, with or without Everolimus for Therapy of Metastatic Malignant Melanoma

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